Lomotil overdose

Definition:
Poisoning from an overdose of Lomotil, an anti-diarrheal, which is a medication comprised of a narcotic agent (opoid derivative) and atropine.

Alternative Names:
Diphenoxylate and Atropine

Poisonous Ingredient:
  • diphenoxylate
  • atropine


Where Found:
  • Lomotil
  • Lofene
  • Logen
  • Lomanate
  • Lonox
Note: This list may not be all inclusive.

Symptoms:
Note: Symptoms of toxicity may take up to 12 hours to appear.

Home Treatment:
Call Poison Control.

Before Calling Emergency:
Determine the following:
  • the patient's age, weight, and condition
  • the name of the product (ingredients and strengths if known)
  • the time it was swallowed
  • the amount swallowed
  • it the medication was prescribed for the patient


Poison Control, or a local emergency number:
They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room:
Some or all of the following procedures may be performed:
  • Induce emesis.
  • Use gastric lavage.
  • Administer activated charcoal.
  • Administer a laxative.
  • Administer a counteracting medication (narcotic antagonist).
  • Children may be kept for observation.


Expectations (prognosis):
After a narcotic antagonist is given, recovery is usually within 24 to 48 hours. Children are at risk of a very poor outcome.



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