Acetaminophen and codeine

Definition:
This poisoning is from an overdose of acetaminophen with codeine.

Alternative Names:
Tylenol # 3

Poisonous Ingredient:
  • Acetaminophen
  • Codeine


Where Found:
  • Tylenol No. 3
Note: This list may not be all inclusive.

Symptoms:
  • Respiratory
  • Eyes, ears, nose, and throat
    • Pinpoint pupils (from the codeine)
  • Skin
  • Gastrointestinal
    • Spasms of the stomach and/or intestinal tract
    • Vomiting
    • Acetaminophen overdose over a certain toxic level leads to liver failure unless the antidote, N-Acetyl-cysteine, is given
  • Heart and blood vessels
  • Nervous system


Home Treatment:
Seek emergency medical care immediately. Both Tylenol and codeine overdoses can be rapidly fatal. DO NOT INDUCE VOMITING.

Before Calling Emergency:
Determine the following information:
  • The patient's age, weight, and condition
  • The name of the product (as well as the ingredients and strength, if known)
  • The time it was swallowed
  • The amount swallowed
  • If the medication was prescribed for the patient


Poison Control, or a local emergency number:
See Poison Control Centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room:
  • For swallowed poison
    • Placement of a tube down the nose and into the stomach (a nasogastric tube, or an NG tube) to wash out the stomach (gastric lavage).
    • Activated charcoal administration.
    • Give IV fluids.
    • Admission to the hospital.
    • For Tylenol, N-Acetyl cysteine is given if the blood Tylenol level is high enough. Without the antidote, the patient has fatal liver failure.
    • Treat the symptoms.
    • Give a counteracting medication (narcotic antagonist). Multiple doses may be needed.


Expectations (prognosis):
If an antidote can be given, recovery from an acute overdose often occurs within 24-48 hours.


The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.