Antidiarrheal agent overdose

Definition:
This is poisoning from overdose of antidiarrheal agents containing diphenoxylate or atropine.

Poisonous Ingredient:
  • diphenoxylate
  • atropine


Where Found:
  • Lomotil
  • Diphenatol
  • Lofene
  • Logen
  • Lomanate
  • Lonox
  • Lo-Trol
  • Nor-Mil
Note: This list may not be all inclusive.

Symptoms:
Note: Symptoms of toxicity may take up to 12 hours to appear

Home Treatment:
The normal treatment is to induce vomiting unless the patient is unconscious or experiencing convulsions; however, before inducing vomiting, contact Poison Control to verify that is the correct treatment.

Before Calling Emergency:
Determine the following information:
  • the patient's age, weight, and condition
  • the name of the product (ingredients and strengths if known)
  • the time it was swallowed
  • the amount swallowed
  • if the medication was prescribed for the patient


Poison Control, or a local emergency number:
They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room:
Some or all of the following procedures may be performed:
  • Use gastric lavage.
  • Administer activated charcoal.
  • Administer a laxative.
  • Administer a narcotic counteracting drug (antagonist) on a regular basis, approximately every 30 minutes.


Expectations (prognosis):
Fatalities can occur in children despite ipecac and charcoal therapy. Patients will normally recover with treatment and 24 hours of monitoring.



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